TECHNOLOGY MATTERS - TOOLS TO COMBAT DISEASE PERPETRATORS

Tissue and organ growth, cell maintenance and death, each of these processes are exquisitely controlled by moving parts invisible to the human eye. Powerful electron microscopes (EMs) were invented to unravel the mystery of how tiny players operate in the body. Even more mysterious is the issue of human disease.

We offer technical expertise in the following areas to help study and combat molecular culprits of disease.

  • Liquid-EM Solutions

    Liquid-EM systems preserve biological samples under fluid conditions as they exist in the body. We are bringing this technology in pharmaceutical settings. Applications include real-time imaging of antibody-drug conjugates, protein aggregation mechanisms, drug delivery systems, engineered nanoparticles, therapeutic peptides, nanobodies, and macromolecules.

  • Cryo-EM Substrate Design

    Cryo-EM is a ground-breaking technique to study biological systems in a pristinely preserved state. This allows us to see the molecular structures of biomaterials. We design custom substrates to better preserve fragile macromolecules for atomic-scale analysis.

  • Structural Virology

    We employ both Liquid-EM and Cryo-EM tools to assess gene therapy vectors, virus-like particles (VLPs), and virus-based vaccine platforms to better inform particle population and characteristics.